Bedaquiline and multidrug-resistant tuberculosis: a systematic and critical analysis of the evidence.
نویسندگان
چکیده
Affiliations: Dept of Infectious Diseases, Galliera Hospital, Genova, Italy. Clinical Epidemiology and Medical Statistics Unit, Dept of Biomedical Sciences University of Sassari – Research, Medical Education and Professional Development Unit, AOU Sassari, Sassari, Italy. WHO Collaborating Centre for TB and Lung Diseases, Fondazione S. Maugeri, Care and Research Institute, Tradate, Italy. Public Health Consulting Group, Lugano, Switzerland. Both authors contributed equally.
منابع مشابه
Combined Use of Delamanid and Bedaquiline to Treat Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: A Systematic Review
The new drugs delamanid and bedaquiline are increasingly being used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB). The World Health Organization, based on lack of evidence, recommends their use under specific conditions and not in combination. No systematic review has yet evaluated the efficacy, safety, and tolerability of delamanid and bedaquiline use...
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in Children. 2nd Edn. WHO/HTM/TB/2014.03. Geneva, World Health Organization, 2014. http://apps.who.int/ medicinedocs/documents/s21535en/s21535en.pdf 6 Bonnet M, Bastard M, du Cros P, et al. Identification of patients who could benefit from bedaquiline or delamanid: a multisite MDR-TB cohort study. Int J Tuberc Lung Dis 2016; 20: 177–186. 7 Pontali E, Sotgiu G, D’Ambrosio L, et al. Bedaquiline a...
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Sir, Charan et al. compared time to conversion of positive sputum to negative and mortality between bedaquiline and placebo. In all the forest plots as heterogenicity, I2 = 0% or nonsignificant, they should have pooled data under fixed‐effect model rather than using random effect model. We have certain observations that need clarifications. Authors’ conclusion with regard to increased mortality...
متن کاملOff-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis
We describe 27 children and adolescents <18 years of age who received bedaquiline during treatment for multidrug-resistant tuberculosis. We report good treatment responses and no cessation attributable to adverse effects. Bedaquiline could be considered for use with this age group for multidrug-resistant tuberculosis when treatment options are limited.
متن کاملExtensively drug-resistant tuberculosis: early access to bedaquiline for a UK patient.
5 Sotgiu G, Centis R, D’Ambrosio L, et al. Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis. Eur Respir J 2012; 40: 1430–1442. 6 Migliori GB, Sotgiu G. Treatment of tuberculosis: have we turned the corner? Lancet 2012; 380: 955–957. 7 De Lorenzo S, Alffenaar JW, Sotgiu G, et al. Efficacy and safety of meropenem...
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ورودعنوان ژورنال:
- The European respiratory journal
دوره 47 2 شماره
صفحات -
تاریخ انتشار 2016